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Invitrogen
Complement C5b Monoclonal Antibody (aE11)
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Product Details
DIA 011-01-02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Horse,
Human,
Non-human primate,
Pig
Published species
C. elegans,
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
aE11
Immunogen
Purified C5b-9.
Conjugate
Form
Liquid
Concentration
1.00 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
DIA 011-01-02 binds both membrane-bound MAC and fluid-phase SC5b-9 complexes from human, porcine, baboon and equine samples.
DIA 011-01-02 has been successfully used in ELISA and IHC applications. This antibody is not recommended for Western blotting as the epitope is destroyed during the process.
Target Information
C5b-9 is also known as the TCC. TCC consists of C5b, C6, C7, C8 and C9. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The complex contains neoantigens that are absent from the individual native components and the monoclonal antibody DIA 011-01 is directed against a neoepitope exposed in C9 when incorporated into TCC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; CHE1; Complement C5; complement component C5; FLJ17816; FLJ17822; MGC142298; prepro-C5
Gene Aliases: C5; C5a; C5b; C5D; CPAMD4; ECLZB
UniProt ID: (Human) P01031
Entrez Gene ID: (Human) 727, (Horse) 100067655, (Pig) 414437
activation of MAPK activity
in utero embryonic development
chemotaxis
response to stress
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of vascular endothelial growth factor production
negative regulation of macrophage chemotaxis
negative regulation of endopeptidase activity
cytolysis
regulation of complement activation
positive regulation of angiogenesis
cell chemotaxis
positive regulation of chemokine secretion
mitophagy in response to mitochondrial depolarization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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